ICAM1 CLIA Kit for Human(Homo sapiens) | EIAab.comICAM1 CLIA Kit for Human(Homo sapiens)

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ICAM1 (Gene name),

Intercellular adhesion molecule 1 (Protein name ), ICAM1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

ICAM1;

Protein name:

Intercellular adhesion molecule 1(ICAM-1);

Alternative:

Major group rhinovirus receptor;

CD:

CD54;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

Function:

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

532

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

532:

YLYNRQRKIK | KYRLQQAQKG | TPMKPNTQAT | PP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF03921

SMR:

P05362

KEGG:

hsa:3383

MIM:

147840

UniGene:

Hs.643447

String:

P05362

STRING:

9606.ENSP00000264832

Uniprot:

P05362

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ELISA Kit for Human ICAM-1

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E0048r

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ELISA Kit for Human ICAM-1

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E0048m

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ELISA Kit for Human ICAM-1

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E0048d

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ELISA Kit for Human ICAM-1

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E0048h

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ELISA Kit for Human ICAM-1

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E0048b

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96T

CLIA Kit for Human ICAM-1

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U0048b

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96T

CLIA Kit for Human ICAM-1

Cat.:

U0048h

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96T

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CLIA Kit for Human ICAM-1

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U0048d

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96T

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CLIA Kit for Human ICAM-1

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U0048m

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96T

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CLIA Kit for Human ICAM-1

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U0048r

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Polyclonal Antibody for Human ICAM-1

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P0048Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ICAM-1

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P0048Rb-h

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Polyclonal Antibody for Human ICAM-1

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P0048Rb-r

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Monoclonal Antibody for Human ICAM-1

Protein for Human ICAM-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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Citations

[1].

"The study of soluble intercellular adhesion molecule-1 and ghrelin in adolescents with family history of type 2 diabetes"

BW Liu, Q Lu, CM Ma, et al.

From:Endocrine

References

1.

"ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM."
Simmons D. , Makgoba M.W. , Seed B.
Nature331:624-627(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-469
2.

"Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families."
Staunton D.E. , Marlin S.D. , Stratowa C. , Dustin M.L. , Springer T.A.
Cell52:925-933(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-469
3.

"cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1."
Tomassini J.E. , Graham D. , Dewitt C.M. , Lineberger D.W. , Rodkey J.A. , Colonno R.J.
Proc. Natl. Acad. Sci. U.S.A.86:4907-4911(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester."
Voraberger G.F. , Schaefer R. , Stratowa C.
J. Immunol.147:2777-2786(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-469
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

SeattleSNPs variation discovery resource
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT KILIFI MET-56;VARIANTS ARG-241; LEU-352; GLN-397 AND TRP-478
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
10.

"Structural characteristics of the 5' region of the human ICAM-1 gene."
Stade B.G. , Messer G. , Riethmueller G. , Johnson J.P.
Immunobiology182:79-87(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
11.

"The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)."
Walter N.A.R. , Stebbing J. , Messier W.
J. Theor. Biol.232:339-346(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-532;VARIANT GLU-469
tissue: Blood.
12.

"The major human rhinovirus receptor is ICAM-1."
Greve J.M. , Davis G. , Meyer A.M. , Forte C.P. , Yost S.C. , Marlor C.W. , Kamarck M.E. , McClelland A.
Cell56:839-847(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;FUNCTION AS A RHINOVIRUS RECEPTOR
13.

"A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection."
Marlin S.D. , Staunton D.E. , Springer T.A. , Stratowa C. , Sommergruber W. , Merluzzi V.J.
Nature344:70-72(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RHINOVIRUS RECEPTOR
14.

"MUC1 mucin core protein binds to the domain 1 of ICAM-1."
Hayashi T. , Takahashi T. , Motoya S. , Ishida T. , Itoh F. , Adachi M. , Hinoda Y. , Imai K.
Digestion 63 Suppl.1:87-92(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MUC1;FUNCTION
15.

"Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1."
Xiao C. , Bator C.M. , Bowman V.D. , Rieder E. , He Y. , Hebert B. , Bella J. , Baker T.S. , Wimmer E. , Kuhn R.J. , Rossmann M.G.
J. Virol.75:2444-2451(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COXSACKIEVIRUS A21 CAPSID PROTEINS
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-267
tissue: Plasma.
17.

"MARCH-IX mediates ubiquitination and downregulation of ICAM-1."
Hoer S. , Smith L. , Lehner P.J.
FEBS Lett.581:45-51(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
18.

"RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
van Buul J.D. , Allingham M.J. , Samson T. , Meller J. , Boulter E. , Garcia-Mata R. , Burridge K.
J. Cell Biol.178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF26;FUNCTION
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-521 AND THR-530;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-202; ASN-260 AND ASN-267
tissue: Liver.
21.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-145
22.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-267
tissue: Leukemic T-cell.
23.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-521 AND THR-530;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1."
Casasnovas J.M. , Stehle T. , Liu J.H. , Wang J.H. , Springer T.A.
Proc. Natl. Acad. Sci. U.S.A.95:4134-4139(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 28-217
26.

"The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand."
Bella J. , Kolatkar P.R. , Marlor C.W. , Greve J.M. , Rossmann M.G.
Proc. Natl. Acad. Sci. U.S.A.95:4140-4145(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212 IN COMPLEX WITH HUMAN RHINOVIRUS 14
27.

"Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor."
Kolatkar P.R. , Bella J. , Olson N.H. , Bator C.M. , Baker T.S. , Rossmann M.G.
EMBO J.18:6249-6259(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212
28.

"Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."
Shimaoka M. , Xiao T. , Liu J.H. , Yang Y. , Dong Y. , Jun C.D. , McCormack A. , Zhang R. , Joachimiak A. , Takagi J. , Wang J.H. , Springer T.A.
Cell112:99-111(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 28-318 IN COMPLEX WITH ITGAL VWFA DOMAIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-130; ASN-145; ASN-183 AND ASN-202
29.

"Structural basis for dimerization of ICAM-1 on the cell surface."
Yang Y. , Jun C.D. , Liu J.H. , Zhang R. , Joachimiak A. , Springer T.A. , Wang J.H.
Mol. Cell14:269-276(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS) OF 212-477;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-267; ASN-296 AND ASN-385
30.

"The crystal structure of coxsackievirus A21 and its interaction with ICAM-1."
Xiao C. , Bator-Kelly C.M. , Rieder E. , Chipman P.R. , Craig A. , Kuhn R.J. , Wimmer E. , Rossmann M.G.
Structure13:1019-1033(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON CRYOMICROSCOPY (8.0 ANGSTROMS) OF 24-473 IN COMPLEX WITH COXSACKIEVIRUS A21;SUBUNIT
31.

"Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster."
Vora D.K. , Rosenbloom C.L. , Beaudet A.L. , Cottingham R.W.
Genomics21:473-477(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-241 AND GLU-469
32.

"DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
Wenzel K. , Ernst M. , Rohde K. , Baumann G. , Speer A.
Hum. Genet.97:15-20(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-241
33.

"A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya."
Fernandez-Reyes D. , Craig A.G. , Kyes S.A. , Peshu N. , Snow R.W. , Berendt A.R. , Marsh K. , Newbold C.I.
Hum. Mol. Genet.6:1357-1360(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT KILIFI MET-56;ASSOCIATION WITH SUSCEPTIBILITY TO MALARIA
34.

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT KILIFI MET-56;VARIANT GLU-469

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